Macy's disappointing profit and a 11 per cent slump in shares took a toll on the consumer discretionary sector, which fell 0.52 per cent with all of its components in the red.
Kohl's was down about 2 per cent despite beating profit estimate.
"Retail is front-and-center because it has been a sore area for the market over the last year or two," said Adam Sarhan, chief executive officer at 50 Park Investments.
At 9:41 am EDT the Dow Jones industrial average was down 40.78 points, or 0.19 per cent, at 20,902.33, the S&P 500 was down 7.72 points, or 0.32 per cent, at 2,391.91 and the Nasdaq Composite was down 21.11 points, or 0.34 per cent, at 6,108.04.
Ten of the 11 major S&P 500 sectors were lower. Technology was down 0.3 per cent, following losses in Microsoft and Intel.
Shares of Snapchat owner Snap Inc plunged 20 per cent after the company reported a slowdown in user growth and revenue in its first earnings report as a public company.
Straight Path fell 20 per cent after agreeing to be bought by Verizon for $184 per share and terminated an earlier deal with AT&T.
Whole Foods was up 5 per cent after the grocer shook up its board and appointed a new CFO.
Declining issues outnumbered advancers on the NYSE by 1,836 to 718. On the Nasdaq, 1,662 issues fell and 606 advanced.
The S&P 500 index showed six 52-week highs and six lows, while the Nasdaq recorded 28 highs and 16 lows.
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